Abstract
Objective: Here we report the prevalence and predictors of genital CMV infection among HIV infected women in Mwanza, Tanzania. Methods: A total of 255 HIV seropositive women were investigated between August and October, 2014. Demographic and clinical data were collected using standardized data collection tool. Exfoliated cells from endocervix were obtained and detection of CMV DNA was done using real-time polymerase chain reaction (RTPCR). Results: A total number of 255 HIV infected women were enrolled with the mean age of 39.2 ± 9.1.The overall prevalence of genital CMV among HIV infected women was 43(16.7%, 95% CI: 12-21). Inflammatory changes and dysplasia did not show any association with genital CMV infection (p>0.05). Only good socio-economic status (OR=2.36, 95% CI; 1.1-5.02, p=.0.027), young age at first sexual intercourse (OR=2.18, 95% CI; 1.04-4.62, p=0.04) and lower CD4+ counts (OR=2.07, 95% CI; 1.23-3.48, p=.0.027) were found to be independent predictors of genital CMV infection among HIV infected women. Conclusion: A significant proportion of HIV infected women are genitally infected with CMV in the genital tract. More studies to ascertain the clinical role of this virus in the female genital tract are recommended especially in HIV infected women.
Highlights
Cytomegalovirus (CMV) is known to be one of the commonest opportunistic pathogen among HIV/AIDS patients especially before the era antiretroviral therapy [1,2]
A cross sectional hospital based study involving 255 HIV seropositive women was conducted between August and October, 2014 at Bugando Medical Centre (BMC), HIV care and treatment clinic (CTC)
Socio-demographic characteristics A total of 255 HIV infected women was enrolled in the study with mean age of 39.2 ± 9.1419
Summary
A total of 255 HIV seropositive women were investigated between August and October, 2014. Demographic and clinical data were collected using standardized data collection tool. Exfoliated cells from endocervix were obtained and detection of CMV DNA was done using real-time polymerase chain reaction (RTPCR)
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