Abstract
A growing body of evidence supports the view that hematopoietic stem cells (HSCs) are heterogeneous with respect to their self-renewal, lineage, and reconstitution capacities. However, the molecular mechanisms underlying these differences are not well-understood. Because gain- and loss-of-function c-Kit mutants exhibit significant alterations in HSC function, we hypothesized that even small changes in c-Kit signaling would result in profound effects on HSC function, and thus, we investigated whether HSCs (Lin-c-Kit+Sca-1+SLAMf150+CD34-) expressing differing levels of c-Kit may exhibit distinct phenotypes.
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