Abstract

Non-insulin dependent diabetes mellitus (NIDDM) is the most prevalent form of diabetes mellitus (DM) in India. Currently the nomenclature is Type 2 diabetes mellitus (Type 2 DM). About one fourth of these diabetics have a body mass index (BMI) below 19, i.e. low bodyweight Type 2 DM (LB Type 2 DM). They are neither protein deficient nor belong to a poor socio-economic class. LB Type 2 DM more often presents with peripheral neuropathy and infections than coronary artery disease (CAD), hypertension or nephropathy. They achieve good glycemic control with sulphonylurea therapy. The leading causes of death are infection, coma, renal failure and cerebrovascular accident. LB Type 2 DM patients have severe basal hyperglycemia with low circulating levels of insulin while C-peptide levels are similar to those of patients with classic Type 2 DM. Studies on hepatic glucokinase levels and hepatic-microsomal enzyme systems (mixed function oxidase and cytochrome P450) using antipyrine and lidocaine as in vivo probes rev...

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