Abstract
There is limited information on the association of body mass index (BMI) with left ventricular (LV) remodeling corresponding to severity of reduced lung function in patients with chronic obstructive pulmonary disease (COPD). Therefore, we investigated whether BMI is associated with cardiac atrial and ventricular dimensions according to severity of lung functional impairment in Chinese COPD elderly. A total of 563 hospitalized COPD patients with lung function impairment and 184 patients with non-COPD (aged 65–92 years) were collected retrospectively in a cross-sectional study in a university affiliated tertiary hospital in China. BMI and cardiac echocardiographic parameters were compared according to severity of lung functional impairment in COPD patients. BMI was 22.9 ± 3.9 kg/m2 in COPD patients, 24.0 ± 4.1 kg/m2 in non-COPD patients respectively. Reduced BMI, LV mass index, LV wall thickness and left atrial diameter, and dilated right ventricle (RV) existed in COPD patients with severe lung dysfunction as compared the COPD patients with mild to moderate lung functional reduction and non-COPD patients (P < 0.05), while there were no differences in BMI and echocardiographic parameters between the COPD patients with mild to moderate lung functional decline and non-COPD patients (P > 0.05). Logistic regression analysis showed that low BMI (BMI < 18.5 kg/m2) was correlated with reduced LV mass and wall thickness, dilated RV and reduced lung function in the COPD patients with severe lung dysfunction. In conclusion, this study demonstrates that lower BMI is associated not only with dilated RV and impaired pulmonary function, but also it is related to reduced LV mass in Asian COPD elderly with severe lung dysfunction.
Highlights
Chronic obstructive pulmonary disease (COPD), as a prevalent progressive disease, is a leading cause of allcause death in the adult population
There was no significant difference in body mass index (BMI), cardiac structure and function between chronic obstructive pulmonary disease (COPD) patients with mild to moderate lung functional reduction and non-COPD patients (P > 0.05, Table 1)
The present study shows that lowered BMI, left atrial (LA) diameter and left ventricular (LV) mass index, and increased right ventricle (RV) diameter existed in COPD patients with severe lung functional reduction
Summary
Chronic obstructive pulmonary disease (COPD), as a prevalent progressive disease, is a leading cause of allcause death in the adult population. It has been reported that low body mass index (BMI), bodyweight loss and cachexia are correlated with impaired lung function, increased all-cause mortality in COPD patients[4,5,6,7,8]. Up to now, it is unclear whether BMI is related to the left-sided cardiac structural remodeling corresponding to different severity of lung functional reduction in COPD patients. In this study, we analysed data from medical records to investigate if BMI is associated with cardiac remodeling according to different severity of lung functional impairment in Chinese COPD elderly
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.