Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo.

Ke-Hang Xie,Jia-Sheng He,Xiao-Feng Huang,Run-Ni Liu,Yong-Kun Ruan,Chu-Yin Su,Ling-Ling Liu,Qing-Qing Chen,Hua Li,Bao-Xing Wu

doi:10.3389/fneur.2020.601695

Abstract

Objective: To investigate the roles of serum uric acid (UA), bilirubin (BIL), albumin (ALB), and creatinine (CRE) as major intravascular antioxidants, in benign paroxysmal positional vertigo (BPPV).Methods: The serum levels of UA, BIL, ALB, and CRE were retrospectively analyzed in 70 patients with new-onset idiopathic BPPV and 140 age- and sex-matched healthy controls (HCs).Results: Serum UA, BIL, ALB, and CRE levels were significantly lower in the BPPV group than the HC group. Furthermore, serum levels of BIL and ALB were significantly lower in the BPPV group when compared by sex. Multiple stepwise logistic regression revealed that a reduction in serum ALB was independently related to BPPV (odds ratio = 0.688; 95% confidence interval = 0.607– 0.780). Receiver operating characteristic analyses revealed a cut-off value of 45.15 g/L for ALB with a sensitivity of 74.29% (62.97– 83.07%) and specificity of 73.57% (65.71– 80.18%).Conclusions: Serum levels of UA, BIL, ALB, and CRE were lower in BPPV patients, indicating a lower antioxidant status. Furthermore, a reduction in serum ALB was independently associated with BPPV. These results provide insights into the possible roles of oxidative stress in the pathogenesis of BPPV.

Highlights

Benign paroxysmal positional vertigo (BPPV), characterized by dizziness and vertigo, has a lifetime prevalence of more than 2.4% [1]
The study cohort consisted of 210 people, including 70 patients with idiopathic BPPV recruited from the Neurology Department and 140 sex- and age-matched healthy controls (HCs) recruited from the Physical Examination Center at our hospital from January 1, 2015 to December 31, 2018
BMI, body mass index, defined as weight in kilograms divided by the square of height in meters; SBP, systolic blood pressure; DBP, diastolic blood pressure; WBC, white blood cells; HGB, hemoglobin; PLT, blood platelet; CRE, creatinine; ALT, alanine transaminase; AST, aspartate transaminase; ALB, albumin; TSH, thyroid stimulating hormone; TC, total cholesterol; TG, triglycerid; high density lipoprotein cholesterol (HDL), high-density lipoprotein cholesterol; low density lipoprotein cholesterol (LDL), low-density lipoprotein cholesterol; UA, uric acid; total BIL (TBIL), total bilirubin; FBG, fasting blood-glucose

Summary

Introduction

Benign paroxysmal positional vertigo (BPPV), characterized by dizziness and vertigo, has a lifetime prevalence of more than 2.4% [1]. The cause of BPPV is the detachment of otoconia (calcium carbonate crystals) that either float in the semicircular canal or attach to the cupule [2]. At present, there are limited methods and techniques available to evaluate the condition of semicircular canals and vestibules, and the physiopathological explanations of BPPV are mainly speculative. The relapse rate of BPPV in the elderly is reportedly 23.5–50% [4]. Further studies of the mechanism underlying the onset of BPPV could provide new and efficient treatment regimens for residual dizziness and to decrease the recurrence rate

Methods

Results

Discussion

Conclusion