Abstract
Background: The existence of asymptomatic peripheral arterial disease among patients with acute ischemic stroke has been studied and proved. Low ankle brachial index (ABI) is considered as a marker of atherosclerosis, and its relation to stroke severity was documented in some studies. The effect of different alleles of ApoE gene on acute ischemic stroke presentation in patients with low ABI is not known. Objective: To study the effect of ApoE gene polymorphism on stroke severity, outcome and recurrence in patients with asymptomatic peripheral arterial disease identified by low ABI. Methods: Patients with acute ischemic stroke were screened for the presence of asymp-tomatic peripheral arterial disease by estimating the ABI using a pocket Doppler ultrasound device. Assay of ApoE gene was done using the real-time PCR technique. Results: Low ABI was present in 31% of patients with acute ischemic stroke. There was no significant difference among patients with different ApoE alleles regarding the severity of their symptoms. Also, there was no significant difference among patients with normal ABI and those with abnormal ABI regarding the ApoE gene polymorphism. Conclusion: The current study showed that there was no significant relation between ApoE gene polymorphism and low ABI in ischemic stroke patients who had asymptomatic peripheral arterial disease.
Highlights
The existence of asymptomatic peripheral arterial disease among patients with acute ischemic stroke has been studied and proved
The aim of our study is to find an association between low ankle brachial index (ABI) and ApoE polymorphism in ischemic strokes, and their role, severity, outcome and recurrence
Patients with an abnormal ABI had a higher risk of cerebrovascular events (CVS) recurrence compared to those with normal ABI [OR = 8.7 with 95% confidence interval (CI) (2.05 - 37.04)]
Summary
The existence of asymptomatic peripheral arterial disease among patients with acute ischemic stroke has been studied and proved. The effect of different alleles of ApoE gene on acute ischemic stroke presentation in patients with low ABI is not known. Objective: To study the effect of ApoE gene polymorphism on stroke severity, outcome and recurrence in patients with asymptomatic peripheral arterial disease identified by low ABI. Methods: Patients with acute ischemic stroke were screened for the presence of asymptomatic peripheral arterial disease by estimating the ABI using a pocket Doppler ultrasound device. There was no significant difference among patients with different ApoE alleles regarding the severity of their symptoms. Conclusion: The current study showed that there was no significant relation between ApoE gene polymorphism and low ABI in ischemic stroke patients who had asymptomatic peripheral arterial disease
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