Abstract
• LRS reduced weight gain and alleviated fatty liver symptoms in hyperlipidemic rats. • T-α-MCA, β-MCA, HCA and isoLCA were positive correlation with TG, TCHO and LDL-C. • LRS inhibited reabsorption of T-α-MCA, β-MCA, HCA, isoLCA to improve blood lipids. • T-α-MCA, β-MCA, HCA, isoLCA maybe potential biomarkers of screening hyperlipidemia. We investigated the effects of lotus seed resistant starch (LRS) on blood lipid lowering and serum bile acids profiles of hyperlipidemic rats, and construct the relationship between serum lipid profile and bile acids. Normal rats or hyperlipidemic rats were gavage with LRS for consecutive 4 weeks. The results showed that LRS slowed down the weight gain and liver index increase in hyperlipidemic rats, alleviated fatty liver symptoms, and improved blood lipid levels. Furthermore, bile acid-targeted metabolomics and correlation analysis showed that T-α-MCA and GDCA had negative correlation with HDL-C, while β-MCA and ω-MCA had positive correlation with TG. HCA and isoLCA had positive correlation with TG, TCHO and LDL-C. In short, LRS inhibited the reabsorption of T-α-MCA, β-MCA, ω-MCA, HCA, isoLCA and GDCA, and reduced their content in serum to improved blood lipid in hyperlipidemic rats. Meanwhile T-α-MCA, β-MCA, HCA and isoLCA may be potential biomarkers for screening of hyperlipidemia.
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