Abstract
The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/Tapas, and MARF1/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesis. This review summarizes the diverse biological as well as molecular functions of LOTUS-domain proteins and discusses their roles as helicase effectors, post-transcriptional regulators, and critical cofactors of piRNA-mediated transcript silencing.
Highlights
In 2010, the LOTUS/OST-HTH domain has been identified through two independent bioinformatic studies and named after the animal proteins in which it resides: LOTUS after Limkain, Oskar and Tudor domain-containing proteins 5 and 7, or OST-HTH after Oskar-Tudor domain-containing protein 5 (TDRD5)/TDRD7 – helix-turn-helix, respectively (Anantharaman et al 2010; Callebaut and Mornon 2010)
The LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/ Tapas, and Meiosis arrest female 1 (MARF1)/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesis
In 2010, the LOTUS/OST-HTH domain has been identified through two independent bioinformatic studies and named after the animal proteins in which it resides: LOTUS after Limkain, Oskar and Tudor domain-containing proteins 5 and 7, or OST-HTH after Oskar-TDRD5/TDRD7 – helix-turn-helix, respectively (Anantharaman et al 2010; Callebaut and Mornon 2010)
Summary
In 2010, the LOTUS/OST-HTH domain has been identified through two independent bioinformatic studies and named after the animal proteins in which it resides: LOTUS after Limkain, Oskar and Tudor domain-containing proteins 5 and 7, or OST-HTH after Oskar-TDRD5/TDRD7 – helix-turn-helix, respectively (Anantharaman et al 2010; Callebaut and Mornon 2010). The LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/ Tapas, and MARF1/Limkain B1, all of which play essential roles in animal development, in particular during oogenesis and/or spermatogenesis.
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