LOTUS: A randomized, phase II, multicenter, placebo-controlled study of ipatasertib (Ipat, GDC-0068), an inhibitor of Akt, in combination with paclitaxel (Pac) as front-line treatment for patients (pts) with metastatic triple-negative breast cancer (TNBC).

Abstract

TPS1111 Background: The PI3K/Akt pathway is often activated in TNBC through loss of PTEN expression, low INPP4B expression, and/or increased AKT3 amplification. Activation of Akt may then lead to c...