Abstract
When homologous interference is established in chick cells through the use of ultraviolet-irradiated Newcastle disease virus, the host cells lose their ability to adsorb active virus. After adsorption of about 10 irradiated particles per cell, specific anti-NDV serum can restore the cells to their original infectible state if employed within 30 minutes after exposure to the interfering agent. The ability of cells to adsorb virus was still absent 49 hours after the addition of irradiated virus. The induction of interference was shown to be temperature-dependent and there was some correlation between the enzymatic activity of the virus and its interfering ability. The data suggest that the interfering agent modifies the cell surface from an extracellular position.
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