Loss of TRIM33 in Multiple Myeloma correlates with increased genomic instability

Abstract

Genomic instability is a hallmark of Multiple Myeloma (MM), with almost all patients displaying cytogenetic abnormalities including ploidy changes, deletions, amplifications and translocations. A common recurrent genetic event in MM with prognostic significance is the deletion of chromosome 1p. TRIM33, an E3 ligase, is located within this deleted region at 1p13. Recent studies demonstrate a role for TRIM33 in the PARP-dependent DNA Damage Response (DDR) and showed that loss of TRIM33 results in the accumulation of chromosomal abnormalities.