Abstract
Loss of Tricho-Rhino-Phalangeal Syndrome-1 (TRPS1) expression as a Biomarker of Poor Prognosis in Patients with Gastric Cancer
Highlights
Gastric cancer (GC) is one of the most common malignancies with increasing incidence worldwide [1]
Down regulation of Tricho-rhino-phalangeal syndrome-1 (TRPS1) expression was associated with distant metastasis and was an unfavorable prognostic factor in patients with gastric cancer (GC), providing us with a novel prognostic marker and a potential therapeutic target. miR221 and miR222 were suggested to have a role in regulation of TRPS1 expression in GC
The expression of TRPS1 was assessed by immunohistochemical staining using a tissue microarray (Figure1)
Summary
Gastric cancer (GC) is one of the most common malignancies with increasing incidence worldwide [1]. Investigations into molecular mechanism involved in malignant feature of gastric cancer are needed to establish novel biomarkers for the early detection and/or the prediction of its prognosis. Tricho-rhino-phalangeal syndrome-1 (TRPS1), a multi zinc-finger nuclear protein, is implicated in trichorhinophalangeal syndrome (TRPS), a genetic disorder characterized by short stature, cone-shaped ends of the long bones, and distinctive facial features linked to skeletal abnormalities [5,6,7]. TRPS1 regulates cell proliferation, epithelial-to-mesenchymal transition (EMT), differentiation and apoptosis essentially in bone and cartilage during development [8,9,10,11,12,13]. Tricho-rhino-phalangeal syndrome-1 (TRPS1), a multi zinc-finger nuclear protein, has been reported to regulate cell proliferation, epithelial-to-mesenchymal transition (EMT), differentiation and apoptosis during development and tumor progression. The aim of this study was to investigate clinico-pathological significance of TRPS1 expression in gastric cancer (GC)
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