Abstract
Loss of RUNX1 function results in enhanced granulocyte-colony-stimulating factor-mediated mobilization.
Highlights
RUNX1 is a transcription factor that regulates many essential aspects of hematopoiesis
Loss of normal RUNX1 function results in enhanced mobilization upon granulocyte-colony stimulating factor (G-CSF) treatment, and even more mobilization upon a combination regimen of G-CSF and AMD3100, a CXCR4 inhibitor. These findings suggest that RUNX1 mutation status should be evaluated before treatment with Hematopoietic stem cells (HSCs) mobilization reagents
These results suggest that loss of RUNX1 in the adult setting leads to hypersensitivity to G-CSF treatment and more mobilization of HSCs
Summary
RUNX1 is a transcription factor that regulates many essential aspects of hematopoiesis. Loss of normal RUNX1 function results in enhanced mobilization upon G-CSF treatment, and even more mobilization upon a combination regimen of G-CSF and AMD3100, a CXCR4 inhibitor.
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