Abstract
Pancreatic cancer has one of the worst prognoses of allgastrointestinal malignancies. One of the key proteins in themechanism of apoptosis is apoptosis protease-activating factorAPAF-1. The aim of this study was to determine expression ofAPAF-1 mRNA in pancreatic cancer. Real time PCR for APAF-1 mRNA was performed on 29 pancreatic cancer cases. Theassociation of APAF-1 mRNA expression with clinico-pathological features was analysed. APAF-1 mRNA expression was lower in 82.8 % in pancreatic cancer than in healthy tissues. The difference was found statistically significant (p=0.02). No association was found between APAF-1 mRNA expression in cancerous tissues and clinico-pathological features. To conclude, in this study we have demonstrated mRNA decrease of APAF-1, indicating that gene involved in cellular apoptosis might be involved in pancreaticcancer pathogenesis.
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