Abstract
There occurs a unique, statistically significant fall in the level of phospholipid in the skin of albino rats bearing large Walker carcinosarcomata 256. The shift is similar to that produced by application of methylcholanthrene. It is preceded by loss of skin weight and increases in levels of skin water, cholesterol, and cholestrol esters. It is accompanied by loss of skin neutral fat and cholesterol esters. The quadratic shift in cholesterol esters occurs in hair before it occurs in skin, and is accompanied by a loss of hair weight and a slight but significant rise in levels of hair neutral fat. Declining levels of skin phospholipid may be part of the mechanism of production of the sallow appearance of the skin in late malignancy.
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