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Abstract
Background: Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a form of microsatellite instability (MSI) that is present at high frequencies in colorectal cancer (CRC). Some reports have recently pointed at mismatch-repair member MSH3 being the putative culprit of its development. MSH3 is part of a complex crucial in repairing both natural and potentially oncogenic mismatches during DNA synthesis and as such it is a ubiquitously expressed protein whose subtle loss might go unnoticed under manual review. This study aims at assessing MSH3 aptness to identifying EMAST-positive tumors and to develop a sensitive, automated and digitalised method of MSH3 protein analysis in immunohistochemically stained tumor slides.
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