LOSS OF HOMOARGININE IS RESPONSIBLE FOR CARDIAC DYSFUNCTION IN CREATINE-DEFICIENT ARGININE:GLYCINE AMIDINOTRANSFERASE (AGAT) KNOCKOUT MICE

Abstract

RationaleCreatine is an intrinsic component of cardiac energy metabolism. We therefore hypothesised that genetic deletion of the creatine biosynthetic enzyme, arginine:glycine amidinotransferase (AGAT KO), would result in impaired cardiac function...