Loss of Heart Rate Variability in Parkinson's Disease Shown by the Poincare Plots during Rhytmic Breathing (P05.196)

Abstract

Objective: To study the variability of the heart rate with Poincare plot in patients with Parkinson9s disease (PD). Background The loss of heart rate variability (HRV) has been demonstrated in a large proportion of patients with PD. During rhythmic breathing (RB) the cycles of bradycardia and tachycardia are readily observed and the time series of RR intervals (RRI) are stationary. Poincare plots obtained during this condition are relatively easy to make and have a clearcut interpretation. Design/Methods: We studied seven patients with PD and compared their HRV to twenty healthy controls. We studied standard deviation 1 (SD1, transverse SD), SD2 (longitudinal SD), SD2/SD1 ratio and the total area of the ellipse (Cn). We also made the FFT of time series of the RRI and constructed frequency plots at low and high frequencies (LF, HF). We also obtained the peak frequency of HF and LF. The frequency of respiratory movements was 0.1 Hz Results: All the studied variables were abnormally low in the patients with PD (SD1 12.24±5.21, SD2 33.8±17.02, Cn 1473.01±1100.23, SD2/SD1 2.79±0.97) compared to the healthy controls (SD1 43.86±21.15, SD2 130.79±52.24, Cn 21190.31±18479.28, SD2/SD1 3.13±0.50) and the data reported in the literature. The analysis in the frequency domain showed a shift to the right of the peak of LF and HF domains. Conclusions: The decrease in SD1, SD2, SD2/SD1 ratio and Cn revealed severe cardiosympathetic and cardiovagal damage. The shift to the right of LF and HF peaks in the frequency plots reveal a delay of response of the cardiosympathetic and cardiovagal reflexes. Poincare plots could be useful in clinical practice for the cardiovascular autonomic evaluation of these patients. Disclosure: Dr. Estanol has nothing to disclose. Dr. Delgado has nothing to disclose. Dr. Bertado has nothing to disclose. Dr. Callejas has nothing to disclose. Dr. Medina has nothing to disclose. Dr. Infante has nothing to disclose. Dr. Lerma has nothing to disclose.