Abstract
DICER1 plays an important role in RNA-induced gene silencing. The biological function of DICER1 is diverse and is implicated in formation of heterochromatin in vertebrate cells, mouse development, female fertility, apoptosis and cancer. The aim of this study was to investigate the role of Dicer protein, in neuronal and non-neuronal cells, under various conditions of cellular stress – thermal stress, defects in protein quality control and accumulation of aberrant cellular proteins. Using a cellular DICER1 knockdown model, we showed that DICER1 plays a role in protecting cells from toxicity induced by thermal stress and defects in the autophago-lysosomal pathways. We also evaluated the role of DICER1 in misfolded proteins disorders such as Huntington's disease and Parkinson's disease. Dicer has a modifier role in protein conformational disorders. Altogether, this study reveals a novel role of DICER1 in human neurodegenerative disorders.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
