Abstract
The effect of adrenaline on the amount of blood eosinophils (eosinophilia) which had been found in Swiss mice in earlier experiments was lost after a few generations. The hyperglycermic response to adrenaline had not been changed. Sensitivities to noradrenaline and adrenaline were as found earlier, but the sensitivity to isoprenaline was reduced. The reduction of β-adrenergic responsiveness suggests variations in biochemical parameters of mice or the appearance of mice genetically less responsive to β-adrenergic drugs in only a few generations.
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