Abstract
Urticaria is a common skin disease, which, in its chronic form, is a very disturbing condition. Because histamine is the best-documented chemical mediator of urticaria, histamine 1-antagonists are the mainstay of therapy. First-generation anti-histamines are limited by their tendency to produce sedation and anticholinergic side effects. Most of the newer second-generation antihistamines compare well with the earlier agents in efficacy but are not limited by the same adverse side effects. Loratadine may be distinguished from other second-generation antihistamines by its pharmacodynamics profile, as well as its tolerability and safety.
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