Looking Into the Future of Diabetes Care with the Sodium Glucose Co-Transporter-2 Inhibitors

Abstract

The initial fear was that worsening of renal function would occur. Current findings suggest that fear is not true and perhaps these agents may be protective of renal function. Recent evidence suggests that the SGLT-2 inhibitors may reduce microalbuminuria [2]. There can be correction of diabetes induced renal hyperperfusion and hyperfiltration [3]. There is reduced proximal sodium absorption leading to an increase in distal delivery of sodium to the macula densa with a subsequent reduction in intra glomerular pressure with decreased RAAS activation [3,4].