Abstract
The article in this issue "Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort," by Cirillo and colleagues, is the first to report multigenerational health effects in granddaughters stemming from early life exposures to the pesticide o,p'-DDT in grandmothers. Health effects associated with F0 environmental chemical exposures in multiple generations have been reported in rodent studies, but not in humans. The striking finding in this body of work by Cohn and her colleagues is that the granddaughters were never directly exposed to o,p'-DDT-only their grandmothers were, potentially when they were adolescents. The increased rise of obesity and early menarche due to o,p'-DDT exposures generations earlier may help explain why it has been so difficult to describe environmental contributors of disease. Have we been looking for exposures in the wrong generation?See related article by Cirillo et al., p. 1480.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
