Abstract
The emergence of antibiotic-resistant pathogenic bacteria in recent decades leads us to an urgent need for the development of new antibacterial agents. The species of the genus Amycolatopsis are known as producers of secondary metabolites that are used in medicine and agriculture. The complete genome sequences of the Amycolatopsis demonstrate a wide variety of biosynthetic gene clusters, which highlights the potential ability of actinomycetes of this genus to produce new antibiotics. In this review, we summarize information about antibiotics produced by Amycolatopsis species. This knowledge demonstrates the prospects for further study of this genus as an enormous source of antibiotics.
Highlights
IntroductionAbout a hundred years ago, Alexander Fleming described the suppression of bacterial growth in an agar medium under the action of a certain substance released into the environment by a fungus colony growing nearby
The science of antibiotics was formed in the twentieth century
In our review we focus on antibiotics produced by genus Amycolatopsis, including the history of their discovery, the emergence of resistance, and the current state of the new drug discovery problem
Summary
About a hundred years ago, Alexander Fleming described the suppression of bacterial growth in an agar medium under the action of a certain substance released into the environment by a fungus colony growing nearby. This fungus was Penicillium chrysogenum, and the first discovered antibiotic was called penicillin. An additional problem was the emergence of antibiotic-resistant microorganisms. In our review we focus on antibiotics produced by genus Amycolatopsis, including the history of their discovery, the emergence of resistance, and the current state of the new drug discovery problem
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