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Abstract
BackgroundA report of multiple cases of bile duct cancer at a Japanese printing company raised concern about such cancers. We examined long-term trends in bile duct cancer in Japan.MethodsData from 4 population-based cancer registries were used to calculate incidence between 1985 and 2007, and vital statistics were used to estimate mortality between 1985 and 2011. Age-standardized rates were calculated and analyzed using a joinpoint regression model.ResultsAmong men, the incidence rate of intrahepatic bile duct cancer increased throughout the observation period; among women, it increased until 1996–1998 and remained stable thereafter. The incidence rate of extrahepatic bile duct cancer was stable in men and decreased from 1993–1995 in women. In people aged 30 to 49 years, the incidence rates of intra- and extrahepatic bile duct cancer remained stable or decreased. The mortality rate of intrahepatic bile duct cancer increased in both sexes and in all age groups since 1996, while that of extrahepatic bile duct cancer decreased since 1992. In people aged 30 to 49 years, the mortality rates of intra- and extrahepatic bile duct cancer remained stable and decreased, respectively.ConclusionsThe incidence and mortality rates of intrahepatic bile duct cancer remained stable or increased throughout the observation period. The incidence rate of extrahepatic bile duct cancer remained stable or decreased, and the mortality rate decreased since 1992. In people aged 30 to 49 years, the incidence and mortality rates of intra- and extrahepatic bile cancer remained stable or decreased.
Highlights
In 2012, Kumagai et al reported that a high percentage of workers at a printing company in Osaka had developed and died from intrahepatic bile duct (IHBD) or extrahepatic bile duct (EHBD) cancer.[1]
The incidence rates of IHBD cancer for men and women were highest in age groups 80 to 84 and 75 to 79 years, respectively
The ASRall and age-standardized rates (ASRs)≥50 of IHBD cancer incidence among men increased by 9.1% and 8.6%, respectively, per 2- or 3-year period throughout the observation period (P < 0.05)
Summary
In 2012, Kumagai et al reported that a high percentage of workers at a printing company in Osaka had developed and died from intrahepatic bile duct (IHBD) or extrahepatic bile duct (EHBD) cancer.[1]. Results: Among men, the incidence rate of intrahepatic bile duct cancer increased throughout the observation period; among women, it increased until 1996–1998 and remained stable thereafter. The incidence rate of extrahepatic bile duct cancer was stable in men and decreased from 1993–1995 in women. In people aged 30 to 49 years, the incidence rates of intra- and extrahepatic bile duct cancer remained stable or decreased. In people aged 30 to 49 years, the mortality rates of intra- and extrahepatic bile duct cancer remained stable and decreased, respectively. Conclusions: The incidence and mortality rates of intrahepatic bile duct cancer remained stable or increased throughout the observation period. In people aged 30 to 49 years, the incidence and mortality rates of intraand extrahepatic bile cancer remained stable or decreased
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