Long-term survival of stage A prostate carcinoma, atypical hyperplasia/adenosis and BPH.

Pn Brawn,M Lind,N Bell,Eh Johnson,M Riggs,Vo Speights

doi:10.1038/bjc.1994.215

Abstract

Between 1972 and 1986, 134 patients with stage A carcinoma of the prostate (CAP) were diagnosed at a single Veterans Administration medical centre and followed annually by the hospital tumour registry. Seventy-four were classified as stage A1, defined as non-palpable, well-differentiated CAP, regardless of amount, found unexpectedly on transurethral resection of the prostate (TURP). Twenty-eight were classified as stage A2, defined as non-palpable, moderately or poorly differentiated CAP, regardless of amount, found unexpectedly on TURP. The remaining 32 were reclassified as atypical hyperplasia/adenosis (AH/A) rather than CAP. The survival of each group was compared with the survival of a control group from the same medical centre who had TURPs showing histologically proven benign prostatic hyperplasia (BPH). Survival and tumour progression were similar for patients with stage A1 CAP, AH/A and BPH. Furthermore, patients with stage A1 CAP, with or without therapy, had similar survivals as patients with BPH in each age group (under 65, 65-74 and over 74 years). Stage A2 CAP was associated with a significantly worse survival and more tumour progression. Within stage A1 CAP and stage A2 CAP the percentage of chips with CAP or the amount of CAP removed did not affect survival.

Highlights

Disease progression and survival in patients with stage A carcinomas of the prostate (CAP) have been studied by numerous investigators (Correa et al, 1974; Heaney et al, 1977; Cantrell et al, 1981; Blute et al, 1986; Epstein et al, 1986; Johansson et al, 1992; Jones et al, 1992)
All patients with stage A carcinoma of the prostate (CAP) diagnosed at the Veterans Administration Medical Center, Temple, Texas, USA, between 1972 and 1986 were identified
Stage A CAP diagnosed in open prostatectomies were not included because the surgical procedure, surgical specimen and method of specimen handling was different from stage A CAP diagnosed from TURP tissue

Summary

Introduction

Disease progression and survival in patients with stage A carcinomas of the prostate (CAP) have been studied by numerous investigators (Correa et al, 1974; Heaney et al, 1977; Cantrell et al, 1981; Blute et al, 1986; Epstein et al, 1986; Johansson et al, 1992; Jones et al, 1992). No study has compared the survival of patients with stage A. adenosis (AH/A) or patients with benign prostatic hyperplasia (BPH) within the same patient population. To clarify the prognosis of stage A CAP, AH/A and BPH, we compared the long-term survival of patients with Stage A CAP with patients from the same medical centre who had transurethral resections of the prostate (TURP) showing histologically proven AH/A or BPH

Methods

Results

Conclusion