Long-term survival of arteriovenous fistulas in home hemodialysis patients

Abstract

We report the outcome of arteriovenous (AV) fistulas created and managed by a multidisciplinary team in patients on hemodialysis (HD) over 20 years. We analyzed 432 AV fistulas in 301 home HD patients (12% diabetic; median age 47 years) followed for up to 161 months. Observed end points were spontaneous or surgical AV fistula closure, or construction of a new vascular anastomosis. Survival was analyzed for first and second AV fistulas and predictors of outcome for first AV fistulas. One vascular surgeon constructed 58% of AV fistulas. Three hundred sixty-seven AV fistulas were in the forearm, 64 at or above the elbow, and 1 in the thigh. Four hundred fourteen AV fistulas used in situ vessels, and 18 were autografts. Two hundred thirty-one anastomoses were side-to-side. Only five grafts were placed during this time. There were 131 second and subsequent AV fistulas in 76 patients, 79 (60%) of which required primary construction, and 52 used arterialized vessels from a previous AV fistula. The median time from formation to use for first and second AV fistula, respectively, was 2.39 (SE 0.35) and 3.2 (SE 1.9) months. Assisted survival from first use for first AV fistula was 90% at 1 year, 66% at 5 years, 84% at 1 year, and 72% at 2 years for second AV fistula. AV fistula survival from creation was superior for side-to-side anastomoses (P < 0.0001) and in men (P= 0.05). A multidisciplinary approach has been successful in providing durable AV fistulas for home HD for >95% of consecutive patients entering our program.