Long-term suppression of the responses of auditory nerve fibers to a characteristic-frequency tone by a low-frequency suppressor

Abstract

The classical two-tone suppression requires the characteristic-frequency (CF) tone and the suppressor (SUP) tone to act simultaneously. We report a novel phenomenon whereby the responses to the CF tone alone were ‘suppressed’ by a preceding low-side SUP tone. Increasing the repetition interval to about 3000 ms or longer eliminated such suppression. The magnitude of this ‘long-term’ suppression was not dependent upon fiber CF, but fibers with low spontaneous rates (SR) generally showed more suppression than high-SR fibers did. The suppression threshold was not dependent upon fiber SR. This suppression of the CF responses did not affect the phases of responses to either the CF or SUP tone, or the phase of suppression. This phenomenon is not due to adaptation or fatigue, but due to the presence of the preceding SUP tone. The efferent system, particularly the ‘slow’ effect, might be responsible for it.