Abstract

BackgroundWe assessed the long-term risk of screen-detected and interval breast cancer in women with a first or second false-positive screening result.MethodsJoint analysis had been performed using individual-level data from three population-based screening programs in Europe (Copenhagen in Denmark, Norway, and Spain). Overall, 75,513 screened women aged 50–69 years from Denmark (1991–2010), 556,640 from Norway (1996–2008), and 517,314 from Spain (1994–2010) were included. We used partly conditional Cox hazards models to assess the association between false-positive results and the risk of subsequent screen-detected and interval cancer.ResultsDuring follow-up, 1,149,467 women underwent 3,510,450 screening exams, and 10,623 screen-detected and 5700 interval cancers were diagnosed. Compared to women with negative tests, those with false-positive results had a two-fold risk of screen-detected (HR = 2.04, 95% CI: 1.93–2.16) and interval cancer (HR = 2.18, 95% CI: 2.02–2.34). Women with a second false-positive result had over a four-fold risk of screen-detected and interval cancer (HR = 4.71, 95% CI: 3.81–5.83 and HR = 4.22, 95% CI: 3.27–5.46, respectively). Women remained at an elevated risk for 12 years after the false-positive result.ConclusionsWomen with prior false-positive results had an increased risk of screen-detected and interval cancer for over a decade. This information should be considered to design personalised screening strategies based on individual risk.

Highlights

  • Women with abnormal mammographic findings at screening are recalled for further assessment, including additional imaging and eventually needle biopsy

  • Breast cancer rates stratified by country showed that in all three countries, the highest crude rates of screen-detected and interval breast cancer were found in women with a second false-positive result, and the lowest rates among those with negative tests (Table 2)

  • We found that the risk for both screen-detected and interval breast cancer remained increased 12 years after experiencing the false-positive result

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Summary

Introduction

Women with abnormal mammographic findings at screening are recalled for further assessment, including additional imaging and eventually needle biopsy. We hypothesise that if the longterm increase in risk is similar for screen-detected cancer and for interval breast cancer in women with false-positive results, it suggests that false-positives may be risk markers for breast cancer development later in life rather than precursors of malignancy. We assessed the long-term risk of screen-detected and interval breast cancer in women with a first or second falsepositive screening result. CONCLUSIONS: Women with prior false-positive results had an increased risk of screen-detected and interval cancer for over a decade. This information should be considered to design personalised screening strategies based on individual risk

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