LONG-TERM PROGNOSIS OF PATIENTS WITH CENTRAL CEREBRAL VENTRICULAR ENLARGEMENT

Abstract

One hundred patients with a 3rd ventricle width of 12 mm or more were examined for the fourth time after an average observation period of 18.8 years. A predominant aetiological factor causing ventricular enlargement was found in 27 cases. A multifactorial aetiology was indicated in 73 cases. Two patients had air-encephalographical findings indicating normal pressure hydrocephalus. Sixty-nine patients had died, 8 patients were in need of care and supervision, 12 patients were unable to work; the remaining 11 were able to work to some extent. The group studied had a significantly increased mortality rate. The causes of death were divided into 3 groups: 1. Probably related to the underlying brain disorder. 2. Related to those in an average Norwegian population. 3. Minor disorder usually not leading to death. A poor long-term prognosis was indicated in patients with: 1. Serious associated disease. 2. A relatively high age. 3. Associated cardiovascular disease. 4. Marked degree of ventricular enlargement. 5. Marked enlargement of the temporal horns. 6. Many and/or marked neurological signs. 7. Progressive intellectual deterioration. A relatively good prognosis was indicated by: 1. A moderate ventricular enlargement. 2. Intracranial anomalies or early acquired brain lesion. 3. Few neurological signs. 4. Age below 50 years on first admission. 5. Absence of cardiovascular disease. 6. Favourable social environment.