Abstract
Data concerning the long-term outcomes of endoscopic submucosal dissection (ESD) versus surgery for early gastric cancer (EGC) are limited. We aimed to compare the long-term outcomes of ESD and surgery for patients with EGC. Data were reviewed from patients treated by ESD or surgery for EGC in 2005-2010. The primary outcome was overall survival (OS). Secondary outcomes were disease-specific survival (DSS), disease-free survival (DFS), recurrence-free survival (RFS), treatment-related complications, and hospital stay duration. Among 617 patients, 342 underwent ESD and 275 underwent surgery. The 5-year OS rates were similar between the ESD group and the surgery group (96.9% vs 98.1%, P=0.581). In a propensity-score-matched analysis of 117 pairs, there were no significant differences in the OS rates (96.5% vs 99.1%, P=0.125) and DSS rates (100% vs 99.1%, P=0.317) between the ESD group and the surgery group. The ESD group had a significantly lower DFS rate (90.3% vs 98.0%, P=0.002), a significantly lower RFS rate (95.1% vs 98.0%, P=0.033), a significantly higher early complication rate (6.7% vs 1.5%, P<0.001), a significantly lower late complication rate (0% vs 9.1%, P<0.001), and a significantly shorter median hospital stay (3days vs 10days, P<0.001) than the surgery group. ESD and surgery have comparable OS rates in patients with EGC. ESD has benefits, including a lower late complication rate and shorter hospital stay. However, RFS and DFS rates might be lower after ESD than after surgery.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have