Abstract
A longitudinal epidemiologic investigation on effects of air pollution on chronic nonspecific lung disease (CNSLD) has been conducted in the Dutch municipalities of Vlagtwedde and Vlaardingen. Vlagtwedde is situated in the east of the province of Groningen; it is a rural area without any industrial air pollution. Vlaardingen is a town of around 80,000 inhabitants situated on the northern side of the Nieuwe Waterweg (a branch of the Rhine river) near its entry into the North Sea. The town is polluted by a concentration of oil refineries on the south and southwest side of the river.
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