Long-term effects of pre-surgical stress management for men with early stage prostate cancer undergoing radical prostatectomy (RP)

Abstract

5148 Background: We conducted a randomized trial to examine pre-surgical stress management for men undergoing RP. We previously reported on the short-term benefits in reducing mood disturbances before and after surgery. Methods: One hundred and fifty- eight men were randomly assigned to one of three conditions. Men in the stress management (SM) group discussed their fears and concerns about the upcoming surgery and were taught diaphragmatic breathing, guided imagery, an imaginal exposure to the day of surgery, and exposure to adaptive coping skills. Men in the supportive attention (SA) group discussed their fears and concerns about the upcoming surgery and then a semi-structured interview was conducted. Men in the SM and SA groups met with a clinical psychologist two times prior to surgery, a brief session just prior to surgery, and then again prior to discharge. Men in the usual care (UC) group had no meetings with a psychologist. Men completed psychosocial and quality of life (QOL) measures including distress (BSI-GSI), intrusive thoughts (IES), and QOL (SF-36), at baseline and 6 and 12 months later. Results: Men were primarily Caucasian (78%), married (85%) and highly educated (80% some college or higher). Mixed model analyses, controlling for ethnicity, age, martial status, stage, baseline PSA, Gleason score, and the respective baseline measure, indicated a significant group main effect for SF-36 Role Physical (SF-RP)(p=0.01). Post-hoc analyses revealed significantly higher SF-RP scores for the SM (86) vs. UC (63) group and marginally higher scores for the SM (86) vs. SA (73) group. There was a marginally significant group main effect for pain scores (SF-BP) (p=0.12) with the SM group reporting significantly better pain scores than the UC group (80 vs. 71), and neither group differed from the SA group (77). There was also a group by time effect for general health scores (SF-GH) revealing by 12 months after surgery that the SM (74) and SA (76) groups both reported higher SF-GH scores than the UC group (68). There were no group differences on any of the other outcomes. Conclusions: Results suggest that even a brief pre-surgical stress management intervention is beneficial in terms of improving aspects of QOL 6 and 12 months after RP. Funding: NIMH/NCI RO1MH59432 No significant financial relationships to disclose.