Abstract
Isosorbide dinitrate (ISDN) and molsidomine (MOLS) exert long-term effects [3, 5, 6] on anginal threshold in patients with coronary heart disease. The assessment of regional left ventricular wall motion abnormalities of both contraction and relaxation during exercise is a sensitive tool for early detection of myocardial ischemia independent from symptoms [2]. Therefore, it is reasonable to assume that antianginal long-term effects of both ISDN-and MOLS should be demonstrable by improvement in left ventricular wall motion.
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