Abstract
AbstractKnave, B. Long‐term effects of high intensity flashes on the ERG of the rabbit. Acta physiol. scand. 1970. 78. 478–490.A method was developed allowing long‐term studies on retinal function in the unanesthetized rabbit. High intensity flashes were found to cause long‐lasting reversible excitability changes in the retina. Even a single flash with an intensity of about 7 log units above the electro‐retinographic b‐wave threshold of the dark adapted eye resulted in a depression of the b‐wave which lasted for about a week. Flashes with still higher intensities resulted in an initial increase followed by a long‐term decrease lasting one or two weeks. In additional experiments corresponding reversible changes in the b‐wave threshold were found.The effects described are not due to influences on a shielding pigment or to a central efferent mechanism since the flash effects were also obtained on albino rabbits and after intracranial section of the optic nerve.
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