Abstract
The purpose of this study was to evaluate the long-term effects of half-time photodynamic therapy (PDT) on the retinal sensitivity in eyes with chronic central serous chorioretinopathy (CSC). Twenty-two eyes of 22 patients with chronic CSC were studied. PDT was applied with full-dose verteporfin and half-time laser duration. The best-corrected visual acuity (BCVA) and retinal sensitivity in the central 2 and 10 degrees were evaluated at the baseline, and at 12 and 24 months after the half-time PDT. The retinal sensitivity was determined by Macular Integrity Assessment microperimetry (MAIA, Centervue, Padova, Italy). The results showed that the mean retinal sensitivities in the central 2 and 10 degrees were significantly improved at 12 months (25.6 ± 2.79 dB, median; 26.11 dB, 25.6 ± 2.25 dB, median; 25.65 dB, respectively; P < 0.001) and at 24 months (26.3 ± 2.62 dB, median; 27.38 dB, 26.6 ± 2.21 dB, median; 27.45 dB, respectively; P < 0.001) after the treatment compared to that at the baseline (19.2 ± 3.93 dB, median; 19.34 dB, 20.9 ± 2.92 dB, median; 20.9 dB, respectively). The BCVA was also significantly improved from 0.18 ± 0.19 median; 0.15 logarithm of the minimum angle of resolution (logMAR) units at the baseline to 0.07 ± 0.15 median; 0 logMAR units at 12 months (P < 0.001) and to 0.049 ± 0.16 median; -0.039 logMAR units at 24 months (P < 0.001). We conclude that half-time PDT results in a significant improvement of the mean central retinal sensitivity for at least 24 months in eyes with chronic CSC. Thus, half-time PDT is beneficial in resolving chronic CSC for a relatively long period.
Highlights
Central serous chorioretinopathy (CSC) is characterized by a serous retinal detachment in the macular area
None of the patients had a new leakage in fluorescein angiography (FA) and a new serous retinal detachment (SRD) in the optical coherence tomographic (OCT) images at 24 months after the half-time photodynamic therapy (PDT)
Our results showed that the mean retinal sensitivity in the central 2 and 10 degrees in eyes with chronic CSC was significantly better after half-time PDT at both 12 and 24 months than that at the baseline
Summary
Central serous chorioretinopathy (CSC) is characterized by a serous retinal detachment in the macular area. The serous retinal detachment (SRD) is caused by a leakage of fluid from the choroid into the subretinal space by a breakdown of the barrier in the retinal pigment epithelium (RPE) [1]. Indocyanine green angiographic images have shown hyperpermeable choroidal vessels [2], and enhanced-depth imaging optical coherence tomographic (EDI-OCT) images have shown a thickened choroid in eyes with CSC [3]. Acute CSC is often a self-limiting disorder, and the visual acuity recovers after the resolution of the SRD. Some patients have a recurrence and the eye is defined as having chronic CSC. Chronic CSC can progress to diffuse RPE atrophy [4]
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