Long-term effect of perinatal and postnatal asphyxia on developing human auditory brainstem responses: peripheral hearing loss

Abstract

Peripheral hearing was assessed by examining brainstem auditory evoked responses (BAER) in children who suffered perinatal or postnatal asphyxia, particularly in those with residual neurodevelopmental deficits, to investigate the long-term effect of asphyxia on the developing auditory sensitivity. The BAER data were collected at least 6 months after the episode of asphyxia. Of the children who suffered perinatal asphyxia, hearing loss was found more frequently in those who exhibited residual neurodevelopmental deficits (17.1%) than in those who did not (6.3%), but this difference did not reach statistical significance. This implied that the long-term effect of perinatal asphyxia on the peripheral auditory system and its effect on the central nervous system may be relatively discrete or not closely correlated. The occurrence of hearing loss did not appear to be closely related to the degree of perinatal asphyxia, although hearing loss occurred more frequently in the children after severe asphyxia compared to those after mild asphyxia. There was no evidence for permanent hearing loss in the children who survived severe, prolonged postnatal asphyxia and exhibited residual neurodevelopmental deficits. These findings suggest that a critical period of particular sensitivity to the effect of hypoxia may exist during the development of the human peripheral auditory system. This period may range from some time prenatally to some time shortly after birth, probably the third postnatal month. After that, hypoxia is unlikely to lead to permanent hearing loss.