Year-end Sale % OFF 
Abstract
Sequelae after recovering from undernutrition, mostly early post-natal undernutrition, is a very controversial issue. Basic fibroblast growth factor (bFGF) is an important growth factor acting during wound healing. Our objective was to observe the presence of this growth factor in the skin of undernourished, undernourished/recovered and control animals by immunohistochemical methods. Protein-calorie malnutrition was produced by separating young rats from the mothers for 10 hours/day during the suckling period (21 days after birth). Undernourished rats were then kept on normal food for recovering. Undernutrition and recovered states were assessed by body weight. Animals at the same age, not submitted to undernutrition, were the controls. The results in undernourished group were according to those reported in the literature. Our results also showed, in control animals, higher bFGF availability in wounded area from day 1 up to day 3 after surgery; and higher deficiency on undernourished animals, even after recovery from nutritional depletion, at the same period. It was also interesting to notice the basal bFGF deficiency in recovered animals. The results obtained for the recovered animals support the hypothesis that early malnutrition has late effects on wound healing, even after physical recovery.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
