Abstract
Many studies have demonstrated that late or very late thrombosis after drug-eluting stent (DES) implantation may be related with incomplete neointimal coverage. We investigated long-term (≥2years) results of neointimal coverage following sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES) implantation using optical coherence tomography (OCT). A follow-up angiography with OCT examination was performed in 29 patients with 32 lesions for more than 2years (group 1; 1,066±381days) and 101 patients with 104 lesions at 9months (group 2; 273±33days) after the index procedure. The status of neointimal coverage and stent apposition was evaluated. The number of stents with completely covered struts was higher (25.0% in group 1 vs. 13.5% in group 2, P=0.12). The percentage of uncovered struts (5.4±7.5% in group 1 vs. 8.5±11.6% in group 2, P=0.19) and that of malapposed strut (0.5±1.4% vs. 1.5±4.2%, respectively, P=0.19) were lower in group 1. While the percentage of uncovered and malapposed struts were quite similar in the PES groups between the two groups (P=0.54 and 0.65, respectively), there were lower trends in the percentage of uncovered and malapposed struts in the SES group (P=0.09 and 0.09, respectively). In conclusion, incomplete neointimal coverage was still observed in a majority of DESs and considerable struts were not covered with neointima even at more than 2years after DES implantation. The pattern of neointimal coverage between 9-month and 2-year appeared to be somewhat different between PES and SES.
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