Long‐range fluorine‐proton coupling in 1,2,4‐triazole derivatives

Abstract

AbstractSeveral 1,2,4‐triazole derivatives containing a 2‐fluorophenyl substituent at either the 3‐ or 5‐position and a methyl group at the 4‐position were synthesized. These derivatives exhibit long‐range 19F‐1H and 19F‐13C through‐space coupling in their 1H and 13C nmr spectra between the fluorine and the 4‐methyl group. The close spatial proximity of these nuclei was confirmed by X‐ray analysis and by fluorine irradiated proton observe ({19F}‐1H) NOE difference spectroscopy.