Abstract
We evaluated the long-term stability of a newly developed viscoelastic phantom made of polyacrylamide (PAAm) gel for magnetic resonance elastography (MRE) and ultrasound-based shear-wave elastography (US SWE). The stiffness of the cylindrical phantom was measured at 0, 13 and 18 months. Storage and loss moduli were measured with MRE, and shear-wave speed (SWS) was measured with US SWE. Long-term stability was evaluated in accordance with the Quantitative Imaging Biomarker Alliance (QIBA) profiles for each modality. The initial storage and loss moduli of the phantom were 5.01±0.22 and 1.11±0.15 respectively, and SWS was 2.57±0.04 m/s. The weight of the phantom decreased by 0.6% over the 18 months. When measured with MRE, the stiffness of the phantom decreased and changes to the storage and loss moduli were -3.0% and -4.6% between 0 and 13 months, and -4.3% and 0.0% between 0 and 18 months. The US measurements found that SWS decreased by 2.4% over the first 13 months and 3.6% at 18 months. These changes were smaller than the tolerances specified in the QIBA profiles, so the viscoelastic PAAm gel phantom fulfilled the condition for long-term stability. This new phantom has the potential to be used as a quality assurance and quality control phantom for MRE and US SWE.
Highlights
Elastography is a non-invasive imaging technique that is expected to offer new quantitative biomarkers for the evaluation of tissue stiffness and the diagnosis of disease such as liver fibrosis or tumor malignancies [1,2,3,4]
In an effort to obtain higher stability, we have developed a phantom made of polyacrylamide (PAAm) gel that can be measured with both magnetic resonance (MR) elastography (MRE) and ultrasoundbased shear-wave elastography (US SWE) [16]
The purpose of this study was to evaluate the long-term stability of visco-elasticity for a phantom made of PAAm gel, and to evaluate whether such a phantom meets the requirements to be a standard phantom for MRE and US SWE
Summary
Elastography is a non-invasive imaging technique that is expected to offer new quantitative biomarkers for the evaluation of tissue stiffness and the diagnosis of disease such as liver fibrosis or tumor malignancies [1,2,3,4]. Commercial magnetic resonance (MR)-imaging and ultrasound (US) elastographic systems are available for clinical use [4,5,6]. Longitudinal stability of a multimodal visco-elastic gel phantom for MR and US shear-wave elastography
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