Abstract
The present multicentric study (three centers) deals with the values of plasma and red blood cell fatty acids obtained in a group of 18 preterm newborns after 2 days (D<sub>2</sub>), 15 days (D<sub>15</sub>) and 5 weeks (37th week postconception: 37th wk) of human milk feeding. Analytical methods were randomized between the three centers and quality control was evaluated by repeated analysis of reference samples. 20:4 n–6 varied from 10.71 ± 1.58% to 9.51 ± 1.65 and 10.10 ± 1.42% in plasma phospholipids and from 16.59 ± 3.30% to 14.68 ± 3.14 and 18.24 ± 4.09% in red blood cell phosphatidylethanolamine (RBC-PE) at D<sub>2</sub>, D<sub>15</sub> and 37th wk, respectively, contrasting with the important rise of the precursor (18:2 n–6) in all the fractions studied. In RBC-PE, 22:6 n–3 significantly declined from 3.52 ± 1.03% at D<sub>2</sub> to 2.56 ± 0.83% at D<sub>15</sub> (p < 0.02) and recovered its initial level at 37th wk (4.08 ± 1.94%). The recovery of long chain polyunsaturated fatty acid homeostasis at that time was also confirmed by the decline of 16:1 n–7 in cholesterol esters (10.69 ± 3.92 to 4.32 ± 2.38%).
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