Abstract
Objective One primary assumption underlying the unambiguous interpretation of change in Multiple Sclerosis Walking Scale-12 (MSWS-12) scores over time is longitudinal measurement invariance (i.e., Is the same construct being measured over time?). Such an assumption was tested in the present study over periods of 6 and 12 months in persons with relapsing–remitting multiple sclerosis (RRMS). Method Participants completed a battery of questionnaires that included the MSWS-12 at baseline ( n = 269) and 6-months ( n = 260) and 12-months ( n = 252) follow-up. The data were analyzed using confirmatory factor analysis and a series of nested model comparisons in M plus 3.0. Results The results indicated that the unidimensional measurement model and all of its parameters (e.g., factor loadings and item intercepts) were invariant over periods of 6 and 12 months. Conclusion We provide novel evidence that supports the unambiguous interpretation of scores from the MSWS-12 as a measure of change in walking impairment over time in a sample of persons with MS.
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