Abstract
Findings on maternal 25-hydroxyvitamin D (25[OH]D) and neonatal anthropometry are inconsistent, and may at least be partly due to variations in gestational week (GW) of 25(OH)D measurement and the lack of longitudinal 25(OH)D measurements across gestation. The aim of the current study was to examine the associations of longitudinal measures of maternal 25(OH)D and neonatal anthropometry at birth. This study included 321 mother–offspring pairs enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies–Singletons. This study was a prospective cohort design without supplementation and without data on dietary supplementation. Nevertheless, measurement of plasma 25(OH)D reflects vitamin D from different sources, including supplementation. Maternal concentrations of total 25(OH)D were measured at 10–14, 15–26, 23–31, and 33–39 GW and categorized as <50 nmol/L, 50–75 nmol/L, and >75 nmol/L. Generalized linear models were used to examine associations of 25(OH)D at each time-point with neonate birthweight z-score, length, and sum of skinfolds at birth. At 10–14 GW, 16.8% and 49.2% of women had 25(OH)D <50 nmol/L and between 50–75 nmol/L, respectively. The association of maternal 25(OH)D with neonatal anthropometry differed by GW and women’s prepregnancy BMI (normal (<25.0 kg/m2), overweight/obese (25.0–44.9 kg/m2)). All analyses were stratified by prepregnancy BMI status. Among women with an overweight/obese BMI, 25(OH)D <50 nmol/L at 10–14 GW was associated with lower birthweight z-score (0.56; 95% CI: −0.99, −0.13) and length (−1.56 cm; 95% CI: −3.07, −0.06), and at 23–31 GW was associated with shorter length (−2.77 cm; 95% CI: −13.38, −4.98) and lower sum of skinfolds (−9.18 mm; 95% CI: −13.38, −4.98). Among women with a normal BMI, 25(OH)D <50 nmol/L at 10–14 GW was associated with lower sum of skinfolds (−2.64 mm; 95% CI: −5.03, −0.24), at 23–31 GW was associated with larger birthweight z-scores (0.64; 95% CI: 0.03, 1.25), and at 33-39 GW with both higher birthweight z-score (1.22; 95% CI: 0.71, 1.73) and longer length (1.94 cm; 95% CI: 0.37, 3.52). Maternal 25(OH)D status during pregnancy was associated with neonatal anthropometric measures, and the associations were specific to GW of 25(OH)D measurement and prepregnancy BMI.
Highlights
The classical function of vitamin D is to regulate calcium and phosphorus metabolism in the intestine and bone, recent findings indicate its important role in several other biochemical and physiological processes, including regulation of the immune system, cellular differentiation, and blood pressure [1]
(10–14 gestational weeks (GW)), maternal 25(OH)D was associated with race/ethnicity, prepregnancy body mass index kg/m2 (BMI), education, insurance type, marital status, and Physical activity (PA), but not with maternal age, parity, smoking, season, or clinic location (Table 1)
In addition to investigating maternal 25(OH)D status during different time windows of pregnancy in association with neonatal anthropometry, our study further evaluated whether the impact of maternal vitamin D status on offspring anthropometric measures varied by maternal prepregnancy
Summary
The classical function of vitamin D is to regulate calcium and phosphorus metabolism in the intestine and bone, recent findings indicate its important role in several other biochemical and physiological processes, including regulation of the immune system, cellular differentiation, and blood pressure [1]. Maternal 25(OH)D levels during pregnancy have been considered critical for both maternal health and fetal development [2–6]. Lower maternal 25(OH)D levels have been associated with unfavorable fetal growth outcomes, such as low birth weight, shorter bone length, and small-for-gestational age (SGA) births in some, though not all studies [7–10]. The inconsistent results in the literature may be partially caused by differences in timing of 25(OH)D measurement; for example, some studies have measured maternal 25(OH)D concentration early in pregnancy at 11–13 gestational weeks (GW) [7], while others have been later in pregnancy at 28–32 GW [10]. Rapid cardiometabolic and hormonal changes during pregnancy results in dynamic alterations in maternal 25(OH)D metabolism and circulating concentrations throughout pregnancy [6]. The gestational age when maternal 25(OH)D is measured may play a role in different findings of the associations between 25(OH)D and neonatal anthropometry. Only one study has examined maternal 25(OH)D measured twice during pregnancy (before 16 GW and 24–28 GW)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
