Abstract
BackgroundImmunoglobulin (Ig) E is well-known to play a critical role in allergic diseases. We investigated the association between longitudinal change in total IgE level and the asthma control in patients with adult asthma.MethodsFor this retrospective study, 154 patients with asthma aged 21–82 years were recruited from the allergy and pulmonary units of the Showa University Hospital. Data on longitudinal changes in IgE over the preceding 10 years were collected and logarithmically transformed. Associations between longitudinal change in IgE and clinical characteristics including asthma control test (ACT) score, asthma control, pulmonary function test, and antigen specific IgE, were assessed.ResultsPatients with increased IgE tended to have significantly higher mean age, more episodes of acute exacerbation within a year, lower ACT scores, and used oral corticosteroids more frequently than those with decreased or unchanged IgE. The prevalence of uncontrolled asthma was higher in patients with increased IgE than in those with decreased or unchanged IgE. Mean %FEV1 and FEV1% were lower in patients with increased IgE than in those with decreased or unchanged IgE. Moreover, the prevalence of Aspergillus-specific IgE was higher in patients with increased IgE than in those with decreased or unchanged IgE.ConclusionsThese data suggest that a longitudinal increase in total IgE is associated with both poor asthma control and Aspergillus-specific IgE in patients with adult asthma.
Highlights
Immnoglobulin E (IgE), the fifth and last immunoglobulin to be identified, was first reported in 1966 [1]
An increase or decrease in IgE was arbitrarily designated as a variation of >0.15 log10kU/L
In the present study, we found that patients with a longitudinal increase in total IgE used on-demand oral corticosteroid (OCS)
Summary
Immnoglobulin E (IgE), the fifth and last immunoglobulin to be identified, was first reported in 1966 [1]. Measurements of total and antigen-specific IgE are helpful for diagnosing allergic diseases. IgE is a critical factor for the development of bronchial hyperresponsiveness in asthmatics [2]. Epidemiological studies have shown that total IgE level is higher in patients with asthma, in children, than in non-asthmatics [3,4,5]. Community Respiratory Health Survey data showed that total IgE was associated with new-onset asthma among atopics [6]. The association between total IgE level and non-atopic asthma remains controversial [7,8]. Immunoglobulin (Ig) E is well-known to play a critical role in allergic diseases. We investigated the association between longitudinal change in total IgE level and the asthma control in patients with adult asthma
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