Abstract
Hypertrophic cardiomyopathy & abnormal ventricular compliance (VC) in the infant of the diabetic mother is related to poor maternal glycemic control. We prospectively evaluated cardiac growth, VC, & somatic growth in 11 normal (N) & 8 nongestational insulin dependent diabetic (D) pregnancies using tetal echo from mid gestation to term. Studies were performed at gestational age (GA) P1) 20-26 wks; P2) 27-33 wks; P3) 34-40 wks & P4) 48-72 hrs postnatally. Septal (S) wall thickness (mm) in diastole was obtained using M-mode echo (4 chamber view). Indices of right & left VC were obtained from diastolic tricuspid & mitral E & A wave time velocity integral ratios (TViE/A, MViE/A). Weight (W) in grams was estimated from biparietal diameter & abdominal circumference. Glycemic control was measured from % glycosylated hemoglobin (A1C). Placental resistance was evaluated by the Pulsatility Index (PI) from umbilical artery flow. Values are expressed as the mean ± 1 SD.
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