Abstract
The goal of this project is to develop radionuclide molecular imaging technologies using a clinical pinhole SPECT/CT scanner to quantify changes in cardiac metabolism using the spontaneously hypertensive rat (SHR) as a model of hypertensive-related pathophysiology. This paper quantitatively compares fatty acid metabolism in hearts of SHR and Wistar-Kyoto normal rats as a function of age and thereby tracks physiological changes associated with the onset and progression of heart failure in the SHR model. The fatty acid analog, 123I-labeled BMIPP, was used in longitudinal metabolic pinhole SPECT imaging studies performed every seven months for 21 months. The uniqueness of this project is the development of techniques for estimating the blood input function from projection data acquired by a slowly rotating camera that is imaging fast circulation and the quantification of the kinetics of 123I-BMIPP by fitting compartmental models to the blood and tissue time-activity curves.
Highlights
Hypertrophic cardiomyopathy is a condition in which the heart muscle becomes thick, forcing the heart to work harder to pump blood
The abnormalities of fatty acid metabolism in hypertrophic cardiomyopathy can be recognized by the decreased uptake in single-photon emission computed tomography (SPECT) images [4]
This study was designed to follow the changes in fatty acid metabolism in the left ventricular myocardium associated with the progression of hypertrophy in the spontaneously hypertensive rat (SHR) and, in so doing, develop methodology for data acquisition and data processing techniques of pinhole SPECT acquired data [6,7,8,9,10,11]
Summary
Hypertrophic cardiomyopathy is a condition in which the heart muscle becomes thick, forcing the heart to work harder to pump blood. This study was designed to follow the changes in fatty acid metabolism in the left ventricular myocardium associated with the progression of hypertrophy in the spontaneously hypertensive rat (SHR) and, in so doing, develop methodology for data acquisition and data processing techniques of pinhole SPECT acquired data [6,7,8,9,10,11]. The goal of this project is to develop radionuclide molecular imaging technologies using a clinical dual-modality pinhole SPECT/X-ray computed tomography (CT) scanner
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
