Abstract
Longitudinal DTI changes following cognitive training therapy in a mild traumatic brain injury rat model
Highlights
Traumatic brain injury (TBI) is the leading cause of acquired disability [1]
Unpaired t-tests revealed that the normalised diffusivity values of the mild TBI (mTBI) group were increased compared to the training groups and sham group in the hippocampus 12 weeks post injury (Figure 2, A-B)
In the CCP group we found significant correlations between the diffusion tensor imaging (DTI) metrics (AD, RD, MD and FA) and premature responses (Figure 2, C, E-F) indicating that impulsivity is associated with higher diffusivity values and lower FA values
Summary
Traumatic brain injury (TBI) is the leading cause of acquired disability [1]. Cognitive training therapy is part of a multi-modality rehabilitation program to ameliorate difficulties that TBI patients experience [2] the effect of a cognitive training program on tissue microstructure is far from understood in TBI [3]. We will characterise microstructural changes induced by cognitive training therapy using diffusion tensor imaging (DTI) in a mild TBI (mTBI) rat model and evaluate whether the type of training (memory vs attention) has an influence on recovery following mTBI
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