Abstract
Vitamin D levels remained fairly stable during ageing with increasing levels in persons aged 55-65years old and decreasing levels in persons aged 65-88years old. The seasonal variation was larger than the longitudinal change. Our findings implicate that vitamin D supplementation becomes more important in older age groups and during wintertime. Longitudinal changes in serum 25-hydroxyvitamin D (25-OHD) levels during aging have not been studied extensively. Two studies showed increasing serum 25-OHD levels. One of these studies suggested that there might be decreasing levels in persons aged 65years and older. The objectives of the current study are the following: (1) to examine longitudinal changes in serum 25-OHD levels in different age groups and (2) to describe the seasonal variation in different age groups. Data of the Longitudinal Aging Study Amsterdam (LASA), an ongoing cohort study, were used. Two different cohorts were included: (1) younger cohort: aged 55-65years old at baseline, n = 738, follow-up of 6years and (2) older cohort: aged 65-88years old at baseline, n = 1,320, follow-up of 13years. At baseline, average levels were 56.5nmol/L in the younger cohort and 51.1nmol/L in the older cohort. In the younger cohort, a longitudinal increase in the mean serum 25-OHD levels of 4nmol/L in 6years was observed; in the older cohort, a longitudinal decrease in the mean serum 25-OHD levels of 4nmol/L in 13years was observed. The seasonal variation was ±12nmol/L in the younger cohort and ±7nmol/L in the older cohort. Long-term serum 25-OHD levels remained fairly stable during aging with slightly increasing levels in persons aged 55-65years old and slightly decreasing levels in persons aged 65-88years old. On average, the seasonal variation was larger than the longitudinal change. Our findings implicate that vitamin D supplementation becomes more important in older age groups and during wintertime.
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