Longitudinal associations between bone and adipose tissue biochemical markers with bone mineralization in boys during puberty.

Donvina Vaitkeviciute,Toivo Jürimäe,Katre Maasalu,Jarek Mäestu,Evelin Lätt,Priit Purge,Meeli Saar,Jaak Jürimäe

doi:10.1186/s12887-016-0647-1

Donvina Vaitkeviciute, Toivo Jürimäe + Show 6 more

Open Access

https://doi.org/10.1186/s12887-016-0647-1

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Journal: BMC pediatrics	Publication Date: Jul 20, 2016
Citations: 15	License type: cc-by

Affiliation: University of Tartu

Abstract

BackgroundWe investigated longitudinal relationships between the biochemical markers of bone and adipose tissue with bone mineral content (BMC), bone mineral density (BMD), moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) in pubertal boys.MethodsNinety-six boys (11.9 ± 0.6 years old) were measured at baseline, after 12 and 24 months. Body composition (fat mass [FM], lean body mass [LBM]), and whole body (WB), lumbar spine (LS) and femoral neck (FN) BMD and BMC were assessed. Additionally, serum leptin, adiponectin, osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX) were measured.ResultsOC had a strong longitudinal inverse effect on changes in WB_BMD (p < 0.001) and LS_BMD (p = 0.021), while CTX had an inverse effect only on changes in FN_BMD (p = 0.011). Leptin had an inverse effect on changes in WB_BMC/WB_BMD (p = 0.001), FN_BMD (p = 0.002) and LS_BMD (p = 0.001). MVPA showed a longitudinal inverse effect on changes in leptin (p = 0.030), however no longitudinal effect of SED to biochemical markers of bone and adipose tissue was found.ConclusionsBone metabolism markers have negative effect on bone mineral accrual during puberty. Increases in MVPA affect leptin, suggesting a positive link of MVPA through leptin metabolism on increases in bone mineralization during puberty.

Highlights

We investigated longitudinal relationships between the biochemical markers of bone and adipose tissue with bone mineral content (BMC), bone mineral density (BMD), moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) in pubertal boys
Optimizing peak bone mass during puberty is a key factor for a healthy skeleton in later adult years [1], about 40 % of peak bone mass is accumulated during pubertal maturation [2]
According to our longitudinal results, it could be suggested that bone formation marker (OC) and bone resorption marker (CTX) negatively affect bone mineralization in healthy pubertal boys

Summary

Introduction

We investigated longitudinal relationships between the biochemical markers of bone and adipose tissue with bone mineral content (BMC), bone mineral density (BMD), moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) in pubertal boys. Previous studies have reported negative associations between OC [11, 12], CTX [12] and bone mineral content (BMC) [11] or BMD [12] in male adolescents. Two studies have found no associations [13, 14] between OC [13, 14], CTX [14] and BMD, while one semi-longitudinal study of van Coeverden et al [15] found positive correlation between OC and BMC values in 11–13.8 years old boys. A study with young adult males (25–30 years old) showed that active subjects had significantly higher serum OC level, compared with non-active males [17] These studies are cross-sectional and long-term conclusions cannot be made. There are no longitudinal studies conducted that have reported the associations or effect of PA for CTX in healthy boys during puberty

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